Simon Mathews

Simon Mathews

Assistant Director, Johns Hopkins Armstrong Institute for Patient Safety and Quality at Johns Hopkins Bayview

Armstrong Institute, 750 E. Pratt St, 15th Floor


Head of Clinical Innovation at Johns Hopkins Armstrong Institute for Patient Safety and Quality 

Assistant Professor of Medicine, Johns Hopkins University School of Medicine Division of Gastroenterology and Hepatology

Research Interests:

  • Applying quality and safety focus to the development of technology solutions; current projects involve: examining quality and safety clinical outcomes
  • Using technology to augment care coordination and communication
  • Applying machine learning to aid in improved diagnosis
  • Development of mobile/digital solutions to aid in clinical decision support
  • application of robotics in the clinical environment

Dr. Mathews leads efforts in clinical innovation at the Johns Hopkins Armstrong Institute for Patient Safety and Quality. He is focused on transforming hospitals and health systems into highly reliable organizations that excel in delivering high quality care. He works closely on strategic initiatives at AI including the development of learning healthcare systems, expansion of governance structures for quality and safety, and collaborations with strategic partners including Johns Hopkins University Applied Physics Lab and Ernst & Young. In addition, he works clinically in the Division of Gastroenterology at Johns Hopkins where he is immersed in quality and safety efforts. He earned his medical degree at the Johns Hopkins School of Medicine and completed his clinical training in Internal Medicine and Gastroenterology at Johns Hopkins. Prior to his medical training he also worked briefly in investment banking at Goldman Sachs in New York City. He is a graduate of the University of Virginia where he studied Economics as a Jefferson Scholar.