Complex Systems Approach to Fibrillation
Fibrillation is a disordered state of cardiac excitation that is one of the most common causes of sudden cardiac death, accounting for an estimated 15-20% of all deaths worldwide. Our objective is to understand and control the mechanism that maintains fibrillation by using a multi-scale complex systems approach to analyzing intra- and inter-scale interactions within the cardiac system.
The proposed research will 1) improve our understanding of the mechanism that maintains fibrillation; 2) identify novel targets of catheter ablation of fibrillation; 3) provide tools that enable a multi-scale complex systems approach to understanding and controlling fibrillation; and 4) train the next generation of scientists in multi-disciplinary research.
Hiroshi Ashikaga, MD, PhD
Theory development, animal study and human validation
- Approach That ‘Digitizes’ Crosstalk Among Heart Cells May Help Locate Epicenters of Dangerous Heart Rhythms
- Quantifying Effectiveness of Treatment for Irregular Heartbeat
- Ashikaga H, Aguilar-Rodríguez J, Gorsky S, Lusczek E, Marquitti FM, Thompson B, Wu D, Garland J. Modeling the heart as a communication system. J R Soc Interface 12: 20141201, 2015 (PMCID: PMC4387519)
- Ashikaga H, James RG. Hidden structures of information transport underlying spiral wave dynamics. Chaos 27: 013106, 2017.
- Tao S, Way S, Garland J, Chrispin J, Ciuffo, LA, Balouch MA, Nazarian S, Spragg DD, Marine J, Berger RD, Calkins H, Ashikaga H. Ablation as targeted perturbation to rewire communication networks of persistent atrial fibrillation. PLoS One 12: e0179459, 2017 (PMCID: PMC5497967)
- Aronis KN, Ashikaga H. Impact of number of co-existing rotors and inter-electrode distance on accuracy of rotor localization. J Electrocardiol, In Press
- Ashikaga H, Asgari-Targhi A. Locating order-disorder phase transition in a cardiac system. Preprint: https://arxiv.org/abs/1708.03990
For more information:
Laboratory of Unconventional Electrophysiology