Recent studies show that hand dexterity and strength recover mostly within the first three months after stroke, and that these two critical components of hand function are supported by separate biological systems. However, in most stroke patients, dexterous hand function does not fully recover with the standard rehabilitation therapy. These findings strongly suggest the need for intense rehabilitation targeting hand dexterity in the early post-stroke stages. Currently, the stroke rehabilitation field is missing effective tools to meet this need. Researchers from the Malone Center and the Brain, Learning, Animation, and Movement Laboratory (BLAM) are conducting pilot studies on the Hand Articulation Neurotraining Device (HAND), a portable rehabilitation device for the hand, which can be used in various clinical settings, starting within the hospital, immediately after brain injury, and after discharge, in the patient’s home.